BMS 299897
Cat. No.：YN380145
CAS No. ：290315-45-6
| 产品名称: | BMS 299897 |
| CAS No.: | 290315-45-6 |
| Chemical Name: | 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-benzenebutanoic acid |
| Synonyms: | BMS 299897;BMS299897 |
| 分子量: | 511.94 |
| 分子式: | C₂₄H₂₁ClF₃NO₄S |
| SMILES: | FC1=CC=C(F)C(N([C@@H](C2=C(CCCC(O)=O)C=C(F)C=C2)C)S(C3=CC=C(Cl)C=C3)(=O)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS 299897 是一种磺胺类γ-secretase抑制剂，作用于稳定过表达淀粉样前体蛋白 (APP) 的HEK293 细胞，抑制Aβ产生，IC50为 7 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Tian, G., Sobotka-Briner, C.D., Zysk, J., et al.Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepinesJ. Biol. Chem.277(35),31499-31505(2002)
Barten, D.M., Guss, V.L., Corsa, J.A., et al.Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitorJ. Pharmacol. Exp. Ther.312(2),635-643(2005)
Meunier, J., Villard, V., Givalois, L., et al.The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's diseaseEur. J. Pharmacol.698(1-3),193-199(2013)
