Sulindac sulfide
Cat. No.：YN380209
| 产品名称: | Sulindac sulfide |
| CAS No.: | 49627-27-2 |
| Chemical Name: | 5-fluoro-2-methyl-1Z-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid |
| Synonyms: | |
| 分子量: | 340.41 |
| 分子式: | C₂₀H₁₇FO₂S |
| SMILES: | O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C\C3=CC=C(SC)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sulindac sulfide 是γ-secretase的一个非竞争性抑制剂，其对 γ42-secretase 的IC50值为 20.2 μM。 |
| IC50和靶点: | |
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Kitamura, S., and Tatsumi, K.In vitro metabolism of sulindac and sulindac sulfide: Enzymatic formation of sulfoxide and sulfoneJpn. J. Pharmacol.32(5),833-838(1982)
Brunell, D., Sagher, D., Kesaraju, S., et al.Studies on the metabolism and biological activity of the epimers of sulindacDrug Metab. Dispos.39(6),1014-1021(2011)
Warner, T.D., Giuliano, F., Vojnovic, I., et al.Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysisProc. Natl. Acad. Sci. USA96(13),7563-7568(1999)
Zheng, X., Zhang, L., Zhai, J., et al.The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductaseFEBS Lett.586(1),55-59(2012)
Kung, H.N., Weng, T.Y., Liu, Y.L., et al.Sulindac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cellsPLoS One9(2),1-15(2014)
Williams, C.S., Goldman, A.P., Sheng, H., et al.Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growthNeoplasia1(2),170-176(1999)
