BAY1125976
Cat. No.：YN420002
CAS No. ：1402608-02-9
| 产品名称: | BAY1125976 |
| CAS No.: | 1402608-02-9 |
| Chemical Name: | 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-imidazo[1,2-b]pyridazine-6-carboxamide |
| Synonyms: | BAY-1125976; BAY 1125976 |
| 分子量: | 383.45 |
| 分子式: | C₂₃H₂₁N₅O |
| SMILES: | O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY1125976 是Akt1/Akt2选择性的变构抑制剂；在10 μM ATP 时抑制 Akt1 和 Akt2 活性的IC50值分别为 5.2 nM 和 18 nM。 |
| IC50和靶点: | [{name:"Akt1:5.2 nM (IC50, at 10 μM ATP)"},{name: "Akt2:18 nM (IC50, at 10 μM ATP)"},{name: "Akt3:427 nM (IC50, at 10 μM ATP)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Politz, O., Siegel, F., Bärfacker, L., et al.BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse modelsInt. J. Cancer140(2),449-459(2017)
