L-Leucine-d
Cat. No.：YN420330
CAS No. ：1062161-90-3
| 产品名称: | L-Leucine-d |
| CAS No.: | 1062161-90-3 |
| Chemical Name: | N-[4-[4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid, methyl ester |
| Synonyms: | |
| 分子量: | 528.6058 |
| 分子式: | C28H32N8O3 |
| SMILES: | O=C(OC)NC1=CC=C(C2=NC(N3CCOCC3)=C(C=NN4C5CCN(CC6=CN=CC=C6)CC5)C4=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WYE-687 是一种 ATP 竞争性的mTOR抑制剂，IC50为 7 nM。WYE-687 抑制mTORC1和mTORC2活化。WYE-687 也抑制PI3Kα和PI3Kγ，IC50分别为 81 nM 和 3.11 μM。 |
| IC50和靶点: | [{name:"PI3K alpha:81 nM (IC50)"},{name: "PI3K gamma:3.11 μM (IC50)'}, 'mTORC1', 'mTORC2', {'mTOR:7 nM (IC50)"},{name: "CK1 gamma1:17.8 μM (IC50)"},{name: "p38 alpha:28.9 μM (IC50)"}] |
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| Solvent & Solubility: |
Yu, K., Toral-Barza, L., Shi, C., et al.Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycinCancer Res.69(15),6232-6240(2009)
Cheng, F., Wang, L., Shen, Y., et al.Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agentBiochem. Biophys. Res. Commun.470(2),324-330(2016)
