mTOR/HDAC-IN-1
Cat. No.：YN420331
| 产品名称: | mTOR/HDAC-IN-1 |
| CAS No.: | 1101810-02-9 |
| Chemical Name: | N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)-thiourea |
| Synonyms: | AZD-3147;AZD3147 |
| 分子量: | 517.7 |
| 分子式: | C24H31N5O4S2 |
| SMILES: | S=C(NCCO)NC(C=C1)=CC=C1C2=NC(C3(CC3)S(C4CC4)(=O)=O)=CC(N5CCOC[C@@H]5C)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD3147 是一种有效的、具有口服活性的、选择性mTORC1和mTORC2的双重抑制剂，IC50值为 1.5 nM。AZD3147 对PI3K也具有一定的选择性作用。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pike, K.G., Morris, J., Ruston, L., et al.Discovery of AZD3147: A potent, selective dual inhibitor of mTORC1 and mTORC2J. Med. Chem.58(5),2326-2349(2015)
