NV-5138
Cat. No.：YN420353
CAS No. ：2095886-80-7
| 产品名称: | NV-5138 |
| CAS No.: | 2095886-80-7 |
| Chemical Name: | 2S-amino-5,5-difluoro-4,4-dimethyl-pentanoic acid |
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| 分子量: | 181.1804664 |
| 分子式: | C7H13F2NO2 |
| SMILES: | FC(F)C(C)(C)C[C@H](N)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NV-5138 是一种亮氨酸类似物，是首个具有选择性的、口服活性的脑内的mTORC1的激动剂，与 Sestrin2 结合。NV-5138 可用于抗抑郁的生物研究。 |
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Sengupta, S., Giaime, E., Narayan, S., et al.Discovery of NV-5138, the first selective Brain mTORC1 activatorSci. Rep.9(1),4107(2019)
Kato, T., Pothula, S., Liu, R.-J., et al.Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activationJ. Clin. Invest.129(6),2542-2554(2019)
