Demethylasterriquinone B1
Cat. No.：YN420364
| 产品名称: | Demethylasterriquinone B1 |
| CAS No.: | 78860-34-1 |
| Chemical Name: | 2-[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-buten-1-yl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | DAQ B1; L-783281; Dimethylasterriquinone |
| 分子量: | 506.6 |
| 分子式: | C32H30N2O4 |
| SMILES: | OC(C(C(C1=CNC2=C1C=CC=C2C/C=C(C)\C)=C3O)=O)=C(C4=C(C(C)(C)C=C)NC5=C4C=CC=C5)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Demethylasterriquinone B1 是一种具有选择性的胰岛素受体 (insulin receptor) 激活剂。Demethylasterriquinone B1 刺激IR β亚基的酪氨酸磷酸化，激活PIK3和AKT。 |
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Salituro, G.M., Pelaez, F., and Zhang, B.B.Discovery of a small molecule insulin receptor activatorRecent Prog. Horm. Res.56,107-126(2001)
Tsai, H.J., and Chou, S.Y.A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activationJ. Biomed. Sci.16(68),(2009)
Weber, M.A., Lidor, A., Arora, S., et al.A novel insulin mimetic without a proliferative effect on vascular smooth muscle cellsJ. Vasc. Surg.32(6),1118-1126(2000)
Webster, N.J.G., Park, K., and Pirrung, M.C.Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulatorChembiochem4(5),379-385(2003)
Kim, H., Deng, L., Xiong, X., et al.Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1J. Med. Chem.50(15),3423-3426(2007)
