NVP-BAG956
Cat. No.：YN420366
CAS No. ：853910-02-8
| 产品名称: | NVP-BAG956 |
| CAS No.: | 853910-02-8 |
| Chemical Name: | α,α-dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile |
| Synonyms: | BAG 956 |
| 分子量: | 427.50004 |
| 分子式: | C28H21N5 |
| SMILES: | CC1=NC2=C(N1C3=CC=C(C(C)(C)C#N)C=C3)C4=CC(C#CC5=CC=CN=C5)=CC=C4N=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-BAG956 是一种 ATP 竞争性的PI3K抑制剂，抑制PI3Kδ，PI3Kα，PI3Kγ和PI3Kβ，IC50分别为 34, 56, 112 和 444 nM。 |
| IC50和靶点: | [{name:"PI3Kα:56 nM (IC50)"},{name: "PI3Kβ:446 nM (IC50)"},{name: "PI3Kδ:35 nM (IC50)"},{name: "PI3Kγ:117 nM (IC50)"},{name: "VEGFR1:2.56 μM (IC50)"},{name: "PDK1:240 nM (IC50)"}] |
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| Solvent & Solubility: |
Stauffer, F., Maira, S.M., Furet, P., et al.Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathwayBioor. Med. Chem. Lett.18(3),1027-1030(2008)
Weisberg, E., Banerji, L., Wright, R.D., et al.Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cellsBlood111(7),3723-3734(2008)
