Arnicolide D
Cat. No.：YN420381
CAS No. ：1033739-92-2
| 产品名称: | Arnicolide D |
| CAS No.: | 1033739-92-2 |
| Chemical Name: | |
| Synonyms: | GNE490;GNE 490 |
| 分子量: | 386.47 |
| 分子式: | C18H22N6O2S |
| SMILES: | CC1=NC(=NC=C1C2=NC3=C(C(=N2)N4CCOCC4)SC(=C3)C(C)(C)O)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-490 是一种 (thienopyrimidin-2-yl)aminopyrimidine，一种有效的泛PI3K抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ 和PI3Kγ的IC50分别为 3.5 nM、25 nM、5.2 nM、15 nM。GNE-490 对mTOR具有 >200 倍的选择性 (IC50=750 nM)。GNE-490 显示出对 MCF7.1 乳腺癌异种移植模型有抑制功效。 |
| IC50和靶点: | [{name:"PI3Kα:3.5 nM (IC50)"},{name: "PI3Kβ:25 nM (IC50)"},{name: "PI3Kδ:5.2 nM (IC50)"},{name: "PI3Kγ:15 nM (IC50)"},{name: "mTOR:750 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
