(Z)-Guggulsterone
Cat. No.：YN420069
CAS No. ：39025-23-5
| 产品名称: | (Z)-Guggulsterone |
| CAS No.: | 39025-23-5 |
| Chemical Name: | pregna-4,17Z(20)-diene-3,16-dione |
| Synonyms: | (Z)-Guggulsterone |
| 分子量: | 312.45 |
| 分子式: | C₂₁H₂₈O₂ |
| SMILES: | C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Z-guggulsterone 是印度阿育吠陀药用植物Commiphora mukul的成分，通过引起细胞凋亡 (apoptosis) 来抑制人前列腺癌细胞的生长。 Z-guggulsterone 通过抑制VEGF-VEGF-R2-Akt信号传导轴来抑制血管生成。 |
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Ahn, K.S., Sethi, G., Sung, B., et al.Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1Cancer Res.68(11),4406-4415(2008)
Xiao, D., and Singh, S.V.z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivoMol. Cancer Ther.7(1),171-180(2008)
