GSK-690693
Cat. No.：YN420034
CAS No. ：937174-76-0
规格
价格(RMB)
库存
| 产品名称: | GSK-690693 |
| CAS No.: | 937174-76-0 |
| Chemical Name: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol |
| Synonyms: | GSK690693 |
| 分子量: | 425.48 |
| 分子式: | C₂₁H₂₇N₇O₃ |
| SMILES: | CC(O)(C)C#CC1=NC=C(OC[C@@H]2CNCCC2)C3=C1N=C(C4=NON=C4N)N3CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-690693 是一种 ATP 竞争型的泛Akt抑制剂，对Akt1，Akt2和Akt3的IC50分别为 2 nM，13 nM，9 nM。GSK-690693 也是一种AMPK的抑制剂，影响 ULK1 的活性，并能显著抑制 STING 依赖的 IRF3 的激活。 |
| IC50和靶点: | [{name:"Akt1:2 nM (IC50)"},{name: "Akt3:9 nM (IC50)"},{name: "Akt2:13 nM (IC50)"},{name: "PKCη:2 nM (IC50)"},{name: "PKCθ:2 nM (IC50)"},{name: "PrkX:5 nM (IC50)"},{name: "PAK6:6 nM (IC50)"},{name: "PAK4:10 nM (IC50)"},{name: "PKCδ:14 nM (IC50)"},{name: "PKCβ1:19 nM (IC50)"},{name: "PKCε:21 nM (IC50)"},{name: "PKA:24 nM (IC50)"},{name: "PKG1β:33 nM (IC50)"},{name: "AMPK:50 nM (IC50)"},{name: "PAK5:52 nM (IC50)"},{name: "DAPK3:81 nM (IC50)'}, 'Autophagy'] |
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| Solvent & Solubility: |
Rhodes, N., Heerding, D.A., Duckett, D.R., et al.Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activityCancer Res.68(7),2366-2374(2008)
