AKT inhibitor VIII
Cat. No.：YN420040
CAS No. ：612847-09-3
规格
价格(RMB)
库存
| 产品名称: | AKT inhibitor VIII |
| CAS No.: | 612847-09-3 |
| Chemical Name: | 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one |
| Synonyms: | AKTi-1/2 |
| 分子量: | 551.64 |
| 分子式: | C₃₄H₂₉N₇O |
| SMILES: | O=C1NC2=CC=CC=C2N1C3CCN(CC4=CC=C(C5=NC6=CC(NC=N7)=C7C=C6N=C5C8=CC=CC=C8)C=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AKT inhibitor VIII (AKTi-1/2) 是一种细胞渗透的喹喔啉化合物，能够有效的，选择性的，可逆的抑制Akt1，Akt2和Akt3的活性，IC50值分别为 58 nM，210 nM 和 2119 nM。 |
| IC50和靶点: | [{name:"Akt1:58 nM (IC50)"},{name: "Akt2:210 nM (IC50)"},{name: "Akt3:2119 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Lindsley, C.W., Zhao, Z., Leister, W.H., et al.Allosteric Akt (PKB) inhibitors: Discovery and SAR of isozyme selective inhibitorsBioorg. Med. Chem. Lett.15(3),761-764(2005)
Zhao, Z., Leister, W.H., Robinson, R.G., et al.Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitorsBioorg. Med. Chem. Lett.15(4),905-909(2005)
Calleja, V., Laguerre, M., Parker, P.J., et al.Role of a novel PH-kinase domain interface in PKB/Akt regulation: Structural mechanism for allosteric inhibitionPLoS Biol.7(1),e17(2009)
Logie, L., Ruiz-Alcaraz, A.J., Keane, M., et al.Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cellsDiabetes56(9),2218-2227(2007)
