MK-2206 dihydrochloride
Cat. No.：YN420041
CAS No. ：1032350-13-2
规格
价格(RMB)
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| 产品名称: | MK-2206 dihydrochloride |
| CAS No.: | 1032350-13-2 |
| Chemical Name: | 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, dihydrochloride |
| Synonyms: | MK-2206 (2HCl) |
| 分子量: | 480.39 |
| 分子式: | C₂₅H₂₃Cl₂N₅O |
| SMILES: | O=C1N2C(C3=CC(C4=CC=CC=C4)=C(N=C3C=C2)C5=CC=C(C6(N)CCC6)C=C5)=NN1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-2206 dihydrochloride (MK-2206 (2HCl)) 是一种具有口服活性的，高效选择性的，变构Akt抑制剂，对 Akt1、Akt2 和 Akt3 的IC50分别为 8、12 和 65 nM。许多乳腺癌细胞系、PIK3CA 突变体和 PTEN 丢失细胞系对 MK-2206 dihydrochloride 敏感。具有抗癌活性。 |
| IC50和靶点: | [{name:"Akt1:8 nM (IC50)"},{name: "Akt2:12 nM (IC50)"},{name: "Akt3:65 nM (IC50)"}] |
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Hirai, H., Sootome, H., Nakatsuru, Y., et al.MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivoMol. Cancer Ther.9(7),1956-1967(2010)
Kurosu, T., Nagao, T., Wu, N., et al.Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosisPLoS One8(11),(2013)
