CCT128930
Cat. No.：YN420156
CAS No. ：885499-61-6
规格
价格(RMB)
库存
| 产品名称: | CCT128930 |
| CAS No.: | 885499-61-6 |
| Chemical Name: | 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine |
| Synonyms: | CCT 128930;CCT-128930 |
| 分子量: | 341.84 |
| 分子式: | C₁₈H₂₀ClN₅ |
| SMILES: | ClC1=CC=C(C=C1)CC2(CCN(CC2)C3=NC=NC4=C3C=CN4)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCT128930 是一种有效的选择性Akt2抑制剂 (IC50为 6 nM)，比作用于 PKA 激酶 (IC50为 168 nM) 选择性高 28 倍，比作用于 p70S6K (IC50为 120 nM) 选择性高 20 倍。 |
| IC50和靶点: | [{name:"Akt2:6 nM (IC50)"},{name: "p70S6K:120 nM (IC50)"},{name: "PKA:168 nM (IC50)'}, 'Autophagy', 'Apoptosis'] |
| In Vitro: | |
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| Solvent & Solubility: |
Yap, T.A., Walton, M.I., Hunter, L.J.K., et al.Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930Mol. Cancer Ther.10(2),360-371(2011)
Bottermann, K., Reinartz, M., Barsoum, M., et al.Systematic analysis reveals elongation factor 2 and α-enolase as novel interaction partners of AKT2PLoS One8(6),1-12(2013)
Wang, F.Z., Chang, Z.Y., Fei, H.R., et al.CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibitionBiochimie.103,118-125(2014)
Kim, H., Prasain, N., Vemula, S., et al.Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matricesMicrovasc. Res.101,72-81(2015)
