Miltefosine
Cat. No.：YN420179
CAS No. ：58066-85-6
规格
价格(RMB)
库存
| 产品名称: | Miltefosine |
| CAS No.: | 58066-85-6 |
| Chemical Name: | 2-[[(hexadecyloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt |
| Synonyms: | 米替福新; HePC; Hexadecyl phosphocholine |
| 分子量: | 407.57 |
| 分子式: | C₂₁H₄₆NO₄P |
| SMILES: | O=P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)[O-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Miltefosine是一种广谱抗微生物，抗利什曼原虫，磷脂剂，通过抑制PI3K/Akt活性起作用。Miltefosine 是 CTP 磷酸胆碱胞苷基转移酶 (CCT) 的抑制剂 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Geilen, C.C., Wieder, T., and Reutter, W.Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cellsJ. Biol. Chem.267(10),6719-6724(1992)
Wieder, T., Geilen, C.C., and Reutter, W.Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholineBiochem. J.291(Pt. 2),561-567(1993)
Geilen, C.C., Haase, R., Buchner, K., et al.The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferationEur. J. Cancer27(12),1650-1653(1991)
Espada, C.R., de Castro Levatti, E.V., Boité, M.C., et al.In vitro susceptibility to miltefosine of Leishmania infantum (syn. L. chagasi) isolates from different geographical areas in BrazilMicroorganisms9(6),1228(2021)
Peralta, M.F., Usseglio, N.A., Bracamonte, M.E., et al.Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasisDrug Deliv. Transl. Res.12(1),180-196(2022)
