Ipatasertib
Cat. No.：YN420200
CAS No. ：1001264-89-6
规格
价格(RMB)
库存
| 产品名称: | Ipatasertib |
| CAS No.: | 1001264-89-6 |
| Chemical Name: | (2S)-(4-chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone |
| Synonyms: | GDC-0068; RG7440 |
| 分子量: | 458.00 |
| 分子式: | C₂₄H₃₂ClN₅O₂ |
| SMILES: | ClC1=CC=C([C@@H](CNC(C)C)C(N2CCN(C3=C([C@H](C)C[C@H]4O)C4=NC=N3)CC2)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ipatasertib (GDC-0068) 是一种选择性的，ATP竞争性的pan-Akt抑制剂，抑制Akt1，Akt2，Akt3的IC50分别为 5，18，8 nM。 |
| IC50和靶点: | [{name:"Akt1:5 nM (IC50)"},{name: "Akt3:8 nM (IC50)"},{name: "Akt2:18 nM (IC50)"},{name: "PKA:3100 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Lin, J., Sampath, D., Nannini, M.A., et al.Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor modelsClin. Cancer Res.19(7),1760-1772(2016)
