Capivasertib
Cat. No.：YN420213
CAS No. ：1143532-39-1
规格
价格(RMB)
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| 产品名称: | Capivasertib |
| CAS No.: | 1143532-39-1 |
| Chemical Name: | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide |
| Synonyms: | AZD5363 |
| 分子量: | 428.92 |
| 分子式: | C₂₁H₂₅ClN₆O₂ |
| SMILES: | O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@H](C4=CC=C(Cl)C=C4)CCO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Capivasertib (AZD5363) 是一种口服有效的pan-AKT激酶抑制剂，抑制Akt1，Akt2和Akt3，IC50分别为 3，7 和 7 nM。 |
| IC50和靶点: | [{name:"Akt1:3 nM (IC50)"},{name: "Akt2:7 nM (IC50)"},{name: "Akt3:7 nM (IC50)"},{name: "ROCK2:60 nM (IC50)"},{name: "ROCK1:470 nM (IC50)"},{name: "PKA:7 nM (IC50)"},{name: "P70S6K:6 nM (IC50)'}, 'Autophagy'] |
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| Solvent & Solubility: |
Davies, B.R., Greenwood, H., Dudley, P., et al.Preclinical pharmacology of AZD5363, an inhibitor of AKT: Pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic backgroundMol. Cancer Ther.11(4),873-887(2012)
