Triciribine
Cat. No.：YN420215
CAS No. ：35943-35-2
规格
价格(RMB)
库存
| 产品名称: | Triciribine |
| CAS No.: | 35943-35-2 |
| Chemical Name: | 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
| Synonyms: | API-2; NSC 154020; TCN |
| 分子量: | 320.30 |
| 分子式: | C₁₃H₁₆N₆O₄ |
| SMILES: | OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C3=NC=NC4=C3C(C(N)=NN4C)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Triciribine 是一种 DNA 合成 (DNA synthesis) 抑制剂，也抑制Akt和HIV-1/2，IC50分别为 130 nM 和 0.02-0.46 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yang, L., Dan, H.C., Sun, M., et al.Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing AktCancer Res.64(13),4394-4399(2004)
Wotring, L.L., Passiatore, J.E., Roti Roti, J.L., et al.Effects of the tricyclic nucleoside 6-amino-4-methyl-8-(β-D-ribofuranosyl)- pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine on the viability and cell cycle distribution of L1210 cells in vitroCancer Res.45(12 Pt 1),6355-6361(1985)
Kucera, L.S., Iyer, N.P., Puckett, S.H., et al.Activity of triciribine and triciribine-5'-monophosphate against human immunodeficiency virus types 1 and 2AIDS Res. Hum. Retroviruses9(4),307-314(1993)
