KP-23172
Cat. No.:YN420221
产品名称: | KP-23172 |
CAS No.: | 1374996-60-7 |
Chemical Name: | 6H-indeno[1,2-ε]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-ε]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1) |
Synonyms: | |
分子量: | 448.36 |
分子式: | C₂₀H₈N₁₂O₂ |
SMILES: | O=C1C2=C(C3=NC4=NN=NN4N=C31)C=CC=C2.O=C5C6=NC7=NN=NN7N=C6C8=C5C=CC=C8 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | KP372-1 是一种PI3-K/Akt 通道抑制剂,详见专利 US7196083。 |
IC50和靶点: | |
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Zeng, Z., Samudio, I.J., Zhang, W., et al.Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemiaCancer Res.66(7),3737-3746(2006)