Uprosertib
Cat. No.：YN420230
CAS No. ：1047634-65-0
规格
价格(RMB)
库存
| 产品名称: | Uprosertib |
| CAS No.: | 1047634-65-0 |
| Chemical Name: | N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide |
| Synonyms: | GSK2141795 |
| 分子量: | 429.25 |
| 分子式: | C₁₈H₁₆Cl₂F₂N₄O₂ |
| SMILES: | O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)N[C@@H](CC3=CC=C(F)C(F)=C3)CN |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Uprosertib (GSK2141795) 是一种有效的，选择性的Akt广谱抑制剂，抑制 Akt1/Akt2/Akt3 的活性，IC50值分别为 180/328/38 nM。 |
| IC50和靶点: | [{name:"Akt3:38 nM (IC50)"},{name: "Akt1:180 nM (IC50)"},{name: "Akt2:328 nM (IC50)"},{name: "ROCK1:1570 nM (IC50)"},{name: "ROCK2:1850 nM (IC50)"},{name: "CDK7:2100 nM (IC50)"}] |
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| Solvent & Solubility: |
Pachl, F., Plattner, P., Ruprecht, B., et al.Characterization of a chemical affinity probe targeting Akt kinasesJ. Proteome Res.12(8),3792-3800(2013)
Dumble, M., Crouthamel, M.C., Zhang, S.Y., et al.Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitorPLoS One9(6),e100880(2014)
