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SC79

Cat. No.:YN420258

  • CAS No. :305834-79-1

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    • 产品名称: SC79
      CAS No.: 305834-79-1
      Chemical Name: 2-amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester
      Synonyms:2-氨基-6-氯-alpha-氰基-3-(乙氧羰基)-4H-1-苯并吡喃-4-乙酸乙酯,SC 79
      分子量:364.78
      分子式:C₁₇H₁₇ClN₂O₅
      SMILES:O=C(OCC)C(C#N)C1C(C(OCC)=O)=C(N)OC2=CC=C(Cl)C=C12
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: SC79,一个特异的、能透过血脑屏障的Akt激动剂,可激活胞质中Akt,并抑制 Akt 膜转位。SC79 特异性结合Akt 的PH 结构域。
      IC50和靶点:
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    • Jo, H., Mondal, S., Tan, D., et al.Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal deathProc. Natl. Acad. Sci. USA109(26),10581-10586(2012)

      Li, C., and Siragy, H.M.(Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucoseAm. J. Physiol. Endocrinol. Metab.309(3),E302-E310(2015)

      Yang, W., Yang, Y., Xia, L., et al.MiR-221 promotes capan-2 pancreatic ductal adenocarcinoma cells proliferation by targeting PTEN-AktCell. Physiol. Biochem.38(6),2366-2374(2016)

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