SC66
Cat. No.：YN420266
CAS No. ：871361-88-5
规格
价格(RMB)
库存
| 产品名称: | SC66 |
| CAS No.: | 871361-88-5 |
| Chemical Name: | 2E,6E-bis(4-pyridinylmethylene)-cyclohexanone |
| Synonyms: | SC66,SC 66 |
| 分子量: | 276.33 |
| 分子式: | C₁₈H₁₆N₂O |
| SMILES: | O=C1/C(CCC/C1=C\C2=CC=NC=C2)=C/C3=CC=NC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SC66 是一种Akt抑制剂，降低细胞活力，这种作用存在剂量和时间依赖性，且抑制肝癌 (HCC) 细胞的集落形成和诱导凋亡。 |
| IC50和靶点: | |
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Hennessy, B.T., Smith, D.L., Ram, P.T., et al.Exploiting the PI3K/AKT pathway for cancer drug discoveryNat. Rev. Drug Discov.4(12),988-1004(2005)
Carpten, J.D., Faber, A.L., Horn, C., et al.A transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature448(7152),439-444(2007)
Jo, H., Lo, P.K., Li, Y., et al.Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitinationProc. Natl. Acad. Sci. USA108(16),6486-6491(2011)
