SU6656
Cat. No.：YN420284
CAS No. ：330161-87-0
规格
价格(RMB)
库存
| 产品名称: | SU6656 |
| CAS No.: | 330161-87-0 |
| Chemical Name: | 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
| Synonyms: | SU 6656,SU-6656 |
| 分子量: | 371.45 |
| 分子式: | C₁₉H₂₁N₃O₃S |
| SMILES: | O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。SU6656 可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。SU6656 还能抑制p-AKT。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Blake, R.A., Broome, M.A., Liu, X., et al.SU6656, a selective Src family kinase inhibitor, used to probe growth factor signalingMol. Cell. Biol.20(23),9018-9027(2000)
Bain, J., McLauchlan, H., Elliot, M., et al.The specificities of protein kinase inhibitors: An updateBiochem. J.371(Pt. 1),199-204(2003)
Jin, W., Yun, C., Jeong, J., et al.c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathwayJ. Biol. Chem.283(3),1391-1400(2008)
Distler, J.H.W., and Distler, O.Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosisRheumatology47(Suppl 5),10-11(2008)
Fossey, S.L., Liao, A.T., McCleese, J.K., et al.Characterization of STAT3 activation and expression in canine and human osteosarcomaBMC Cancer9:81,(2009)
