Sophocarpine
Cat. No.：YN420288
CAS No. ：6483-15-4
规格
价格(RMB)
库存
| 产品名称: | Sophocarpine |
| CAS No.: | 6483-15-4 |
| Chemical Name: | (7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-decahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one |
| Synonyms: | 槐果碱 |
| 分子量: | 246.35 |
| 分子式: | C₁₅H₂₂N₂O |
| SMILES: | O=C1C=CC[C@]2([H])[C@@]3([H])CCCN4[C@@]3([H])[C@](CCC4)([H])CN21 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sophocarpine 是从传统草药苦参 (Sophora flavescens) 中提取的重要生物碱之一，苦参具有抗病毒，抗肿瘤，抗炎等多种药理作用。Sophocarpine 通过多种机制显着抑制胃癌细胞的生长，例如诱导自噬 (autophagy)，激活细胞凋亡 (apoptosis) 和下调细胞存活PI3K/AKT信号通路。Sophocarpine 已被证明在各种癌细胞中具有抗肿瘤活性，包括肝细胞癌，前列腺癌和结肠直肠癌。 |
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Lin, Z., Huang, C.-F., Liu, X.-S., et al.In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens AitBasic Clin. Pharmacol. Toxicol.108(5),304-309(2011)
Matsuda, K., Yamada, K., Kimura, M., et al.Nematicidal activity of matrine and its derivatives against pine wood nematodesJ. Agric. Food Chem.39(1),189-191(1991)
Li, C., Gao, Y., Tian, J., et al.Sophocarpine administration preserves myocardial function from ischemia-reperfusion in rats via NF-κB inactivationJ. Ethnopharmacol.135(3),620-625(2011)
C.-Y., S., Zeng, X., Chen, S.-W., et al.Sophocarpine alleviates non-alcoholic steatohepatitis in ratsJ. Gastroenterol. Hepatol.26(4),765-774(2011)
Gao, Y., Li, G., Li, C., et al.Anti-nociceptive and anti-inflammatory activity of sophocarpineJ. Ethnopharmacol.125(2),324-329(2009)
