Cyclovirobuxine D
Cat. No.：YN420290
CAS No. ：860-79-7
规格
价格(RMB)
库存
| 产品名称: | Cyclovirobuxine D |
| CAS No.: | 860-79-7 |
| Chemical Name: | (3β,5α,16α,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol |
| Synonyms: | 黄杨碱 |
| 分子量: | 402.66 |
| 分子式: | C₂₆H₄₆N₂O |
| SMILES: | C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cyclovirobuxine D (CVB-D) 是中药黄杨Buxus microphylla的主要活性成分。Cyclovirobuxine D 诱导自噬并减弱Akt和mTOR的磷酸化。Cyclovirobuxine D 通过抑制细胞周期进程和诱导线粒体介导的细胞凋亡apoptosis抑制癌细胞的增殖。Cyclovirobuxine D 有潜力用于心肌梗死引起的心力衰竭的研究。 |
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Zhao, J., Wang, Q., Xu, J., et al.Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cellsEur. J. Pharmacol.660(2-3),259-267(2011)
Yu, B., Ruan, M., Zhou, L., et al.Influence of cyclovirobuxine D on intracellular [Ca2+] regulation and the expression of the calcium cycling proteins in rat myocytesFitoterapia83(8),1653-1665(2012)
Yu, B., Fang, T.-H., Lü, G.-H., et al.Beneficial effect of cyclovirobuxine D on heart failure rats following myocardial infarctionFitoterapia82(6),868-877(2011)
Guo, Q., Guo, J., Yang, R., et al.Cyclovirobuxine D attenuates doxorubicin-induced cardiomyopathy by suppression of oxidative damage and mitochondrial biogenesis impairmentOxid. Med. Cell. Longev.2015(151972),(2015)
Lu, J., Sun, D., Gao, S., et al.Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cellsJ. Pharmacol. Sci.125(1),74-82(2014)
Wu, J., Tan, Z., Chen, J., et al.Cyclovirobuxine D inhibits cell proliferation and induces mitochondria-mediated apoptosis in human gastric cancer cellsMolecules20(11),20659-20668(2015)
