Crebanine
Cat. No.：YN420305
CAS No. ：25127-29-1
规格
价格(RMB)
库存
| 产品名称: | Crebanine |
| CAS No.: | 25127-29-1 |
| Chemical Name: | (7R)-6,7,7a,8-tetrahydro-9,10-dimethoxy-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline |
| Synonyms: | 克班宁 |
| 分子量: | 339.39 |
| 分子式: | C₂₀H₂₁NO₄ |
| SMILES: | CN1CCC(C2=C3C4=CC=C(OC)C(OC)=C4C[C@@]12[H])=CC5=C3OCO5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Crebanine 是来自于Stephania venosa的一种生物碱，可诱导人类癌细胞的 G1阻滞和凋亡。Crebanine 通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性。Crebanine 还具有抗心律失常的作用。 |
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Rojsanga, P., Boonyarat, C., Utsintong, M., et al.The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptorLife Sci.91(3-4),107-114(2012)
Xiao-Shan, H., Qing, L., Yun-Shu, M., et al.Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytesChin. J. Nat. Med.12(1),20-23(2014)
Deng, Y., Yu, Y., Luo, H., et al.Antimicrobial activity of extract and two alkaloids from traditional Chinese medicinal plant Stephania dielsianaFood Chem.124(4),1556-1560(2011)
Intayoung, P., Limtrakul, P., and Yodkeeree, S.Antiinflammatory activities of crebanine by inhibition of NF-κB and AP-1 activation through suppressing MAPKs and Akt signaling in LPS-induced RAW264.7 macrophagesBiol. Pharm. Bull.39(1),54-61(2016)
Yodkeeree, S., Pompimon, W., and Limtrakul, P.Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene productsTumour Biol.35(9),8615-8624(2014)
