EX229
Cat. No.：YN420090
CAS No. ：1219739-36-2
规格
价格(RMB)
库存
| 产品名称: | EX229 |
| CAS No.: | 1219739-36-2 |
| Chemical Name: | 5-[[6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid |
| Synonyms: | Ex229;5-[[6-Chloranyl-5-(1-Methylindol-5-Yl)-1h-Benzimidazol-2-Yl]oxy]-2-Methyl-Benzoic Acid;4cfe;BDBM50195475;SB19033;5-[6-chloro-5-(1-methylindol-5-yl)-1h-benzimidazol-2-yl]oxy-2-methyl-benzoic acid;5-{[6-chloro-5-(1-methyl-1h-indol-5-yl)-1h-benzimidazo |
| 分子量: | 431.87 |
| 分子式: | C₂₄H₁₈ClN₃O₃ |
| SMILES: | O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(N(C)C=C5)C=C4)C=C3N2)=CC=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EX229 是一个苯并咪唑的衍生物，是 AMP 活化蛋白激酶(AMPK)的有效变构激动剂，其对 α1β1γ1、α2β1γ1 和 α1β2γ1 的Kd值分别为 0.06 μM、0.06 μM 和 0.51 μM。 |
| IC50和靶点: | [{name:"AMPK α1β1γ1:0.06 μM (Kd)"},{name: "AMPK α2β1γ1:0.06 μM (Kd)"},{name: "AMPK α1β2γ1:0.51 μM (Kd)"}] |
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| Solvent & Solubility: |
Lai, Y.-C., Kviklyte, S., Vertommen, D., et al.A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: Comparison with effects of contraction and other AMPK activatorsBiochem. J.460(3),363-375(2014)
Brown, A.E., Dibnah, B., Fisher, E., et al.Pharmacological activation of AMPK and glucose uptake in cultured human skeletal muscle cells from patients with ME/CFSBiosci. Rep.38(3),BSR20180242(2018)
