HTH-01-015
Cat. No.：YN420121
CAS No. ：1613724-42-7
规格
价格(RMB)
库存
| 产品名称: | HTH-01-015 |
| CAS No.: | 1613724-42-7 |
| Chemical Name: | 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one |
| Synonyms: | HTH-01-015;HTH 01 015;5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one;GTPL8977;BCP14400;s7318;AK316255;2,7,;2,7,9-Trimethyl-5-[(1-piperidin-4-ylpyrazol-4-yl)amino]-2,4,6,9-tetr |
| 分子量: | 468.55 |
| 分子式: | C₂₆H₂₈N₈O |
| SMILES: | O=C1C(C=C2C=CC=CC2=C3)=C3N(C)C4=NC(NC5=CN(N=C5)C6CCNCC6)=NC(C)=C4N1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HTH-01-015 是一种选择性NUAK1/ARK5抑制剂 (IC50为 100 nM)。HTH-01-015 抑制 NUAK1 的效力比抑制 NUAK2 高 100 倍以上 (IC50>10 μM)。 |
| IC50和靶点: | [{name:"NUAK1:100 nM (IC50)"}] |
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| Solvent & Solubility: |
Banerjee, S., Buhrlage, S.J., Huang, H.T., et al.Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinasesBiochem. J.457(1),215-225(2014)
