AICAR
Cat. No.：YN420161
CAS No. ：2627-69-2
规格
价格(RMB)
库存
| 产品名称: | AICAR |
| CAS No.: | 2627-69-2 |
| Chemical Name: | 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| Synonyms: | 阿卡地新; Acadesine; AICA Riboside |
| 分子量: | 258.23 |
| 分子式: | C₉H₁₄N₄O₅ |
| SMILES: | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C(N)=O)=C2N)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AICAR (Acadesine) 是一种腺苷类似物，也是一种AMPK激活剂。AICAR 调节葡萄糖和脂质的代谢，并抑制促炎细胞因子和 iNOS 的产生。AICAR 也是一种自噬 (autophagy)，YAP和mitophagy抑制剂。 |
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Corton, J.M., Gillespie, J.G., Hawley, S.A., et al.5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?Eur. J. Biochem.229,558-565(1995)
Salt, I.P., Connell, J.M.C., and Gould, G.W.5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytesDiabetes49,1649-1656(2000)
Ayasolla, K.R., Giri, S., Singh, A.K., et al.5-aminoimidazole-4-carboxamide-Iβ4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astrogliaJ. Neuroinflammation2,1-21(2005)
Samari, H.R., and Seglen, P.O.Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinaseJ. Biol. Chem.273(37),23758-23763(1998)
Kefas, B.A., Heimberg, H., Vaulont, S., et al.AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinaseDiabetologia46(2),250-254(2003)
