Dorsomorphin dihydrochloride
Cat. No.：YN420163
CAS No. ：1219168-18-9
规格
价格(RMB)
库存
| 产品名称: | Dorsomorphin dihydrochloride |
| CAS No.: | 1219168-18-9 |
| Chemical Name: | 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine, dihydrochloride |
| Synonyms: | Compound C dihydrochloride; BML-275 dihydrochloride |
| 分子量: | 472.41 |
| 分子式: | C₂₄H₂₇Cl₂N₅O |
| SMILES: | [H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dorsomorphin dihydrochloride (Compound C dihydrochloride) 是一种有效，选择性和 ATP 竞争性的AMPK抑制剂，Ki为 109 nM。Dorsomorphin dihydrochloride 通过靶向抑制 I 型受体ALK2，ALK3和ALK6来抑制 BMP 途径。Dorsomorphin dihydrochloride 诱导自噬 (autophagy) 作用。 |
| IC50和靶点: | [{name:"AMPK:109 nM (Ki)'}, 'ACVR1', 'BMPR1A', 'ALK6', 'Autophagy'] |
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Zhou, G., Myers, R., Li, Y., et al.Role of AMP-activated protein kinase in mechanism of metformin actionJ. Clin. Invest.108(8),1167-1174(2001)
Yu, P.B., Hong, C.C., Sachidanandan, C., et al.Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismNat. Chem. Biol.4(1),33-41(2008)
Vucicevic, L., Misirkic, M., Janjetovic, K., et al.Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathwayAutophagy7(1),40-50(2011)
