Metformin hydrochloride
Cat. No.：YN420251
CAS No. ：1115-70-4
规格
价格(RMB)
库存
| 产品名称: | Metformin hydrochloride |
| CAS No.: | 1115-70-4 |
| Chemical Name: | N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
| Synonyms: | 盐酸二甲双胍; 1,1-Dimethylbiguanide hydrochloride |
| 分子量: | 165.62 |
| 分子式: | C₄H₁₂ClN₅ |
| SMILES: | NC(NC(N(C)C)=N)=N.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 抑制肝脏中的线粒体呼吸链，导致AMPK活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障，诱导自噬 (autophagy)。 |
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Wheaton, W.W., Weinberg, S.E., Hamanaka, R.B., et al.Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisElife3:e02242,(2014)
Kim, E.K., Lee, S.H., Jhun, J.Y., et al.Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21.Mediators Inflamm.5813030,(2016)
Lin, M.-J., Dai, W., Scott, M.J., et al.Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathwayOncotarget8\(65),108802-108809(2017)
