A-769662
Cat. No.：YN420272
CAS No. ：844499-71-4
规格
价格(RMB)
库存
| 产品名称: | A-769662 |
| CAS No.: | 844499-71-4 |
| Chemical Name: | 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Synonyms: | A 769662 |
| 分子量: | 360.39 |
| 分子式: | C₂₀H₁₂N₂O₃S |
| SMILES: | N#CC1C(C2=C(NC1=O)SC=C2C3=CC=C(C4=CC=CC=C4O)C=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-769662 是一种有效的，可逆的AMPK激活剂，EC50值为 0.8 μM。 |
| IC50和靶点: | [{name:"AMPK:0.8 μM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Göransson, O., McBride, A., Hawley, S.A., et al.Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinaseJ. Biol. Chem.282(45),32549-32560(2007)
Sanders, M.J., Ali, Z.S., Hegarty, B.D., et al.Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone familyJ. Biol. Chem.282(45),32540-32548(2007)
Scott, J.W., van Denderen, B.J.W., Jorgensen, S.B., et al.Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexesChem. Biol.15,1220-1230(2013)
Zhou, Y., Wang, D., Zhu, Q., et al.Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesisBiol. Pharm. Bull.32(6),993-998(2009)
Hsu, M.H., Savas, Ü., Lasker, J.M., et al.Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathwayJ. Pharmacol. Exp. Ther.337(1),125-136(2011)
Treebak, J.T., Birk, J.B., Hansen, B.F., et al.A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscleAm. J. Physiol. Cell Physiol.297,C1041-C1052(2009)
Liu, X.m., Peyton, K.J., Shebib, A.R., et al.Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survivalAm. J. Physiol. Heart Circ. Physiol.300,H84-H93(2011)
