Amarogentin
Cat. No.：YN420306
CAS No. ：21018-84-8
规格
价格(RMB)
库存
| 产品名称: | Amarogentin |
| CAS No.: | 21018-84-8 |
| Chemical Name: | 5-ethenyl-4,4aS,5R,6S-tetrahydro-6-[[2-O-[(3,3',5-trihydroxy[1,1'-biphenyl]-2-yl)carbonyl]-β-D-glucopyranosyl]oxy]-1H,3H-pyrano[3,4-c]pyran-1-one |
| Synonyms: | 苦龙胆酯苷 |
| 分子量: | 586.54 |
| 分子式: | C₂₉H₃₀O₁₃ |
| SMILES: | C=C[C@H]([C@@]1([H])C(C(OCC1)=O)=CO2)[C@@H]2O[C@@](O[C@H](CO)[C@@H](O)[C@@H]3O)([H])[C@@H]3OC(C4=C(C5=CC(O)=CC=C5)C=C(O)C=C4O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amarogentin 是一种裂环烯醚萜苷，主要从Swertia和Gentiana根中提取。Amarogentin 表现出许多生物学效应，包括抗氧化，抗肿瘤和抗糖尿病活性。 Amarogentin 具有保肝和免疫调节作用。Amarogentin 促进细胞凋亡，阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。Amarogentin 通过激活AMPK发挥有益的血管代谢作用。 |
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Medda, S., Mukhopadhyay, S., and Basu, M.K.Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal formsJ. Antimicrob. Chemother.44(6),791-794(1999)
Zhao, J.G., Zhang, L., Xiang, X.-j., et al.Amarogentin secoiridoid inhibits in vivo cancer cell growth in xenograft mice model and induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathwayJ. BUON.21(3),609-617(2016)
Niu, H.S., Chao, P.-C., Ku, P.-M., et al.Amarogentin ameliorates diabetic disorders in animal modelsNaunyn Schmiedebergs Arch. Pharmacol.389(11),1215-1223(2016)
