Kahweol
Cat. No.：YN420310
CAS No. ：6894-43-5
规格
价格(RMB)
库存
| 产品名称: | Kahweol |
| CAS No.: | 6894-43-5 |
| Chemical Name: | 3bS,4,5,6,7R,8R,9,10,10aR,10bS-decahydro-7-hydroxy-10b-methyl-5aS,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol |
| Synonyms: | 咖啡豆醇 |
| 分子量: | 314.42 |
| 分子式: | C₂₀H₂₆O₃ |
| SMILES: | C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)C=C2)C[C@@]([C@](CO)(O)C4)([H])CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Kahweol 是咖啡Coffea Arabica的成分之一，具有抗炎，抗血管生成和抗癌活性。Kahweol 通过激酶 (AMPK) 的活化抑制的脂肪生成adipogenesis和增加葡萄糖摄取。Kahweol 诱导细胞凋亡 (apoptosis)。 |
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Lam, L.K.T., Sparnins, V.L., and Wattenberg, L.W.Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouseCancer Res.42(4),1193-1198(1982)
Cavin, C., Holzhäuser, D., Constable, A., et al.The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanismCarcinogenesis19(8),1369-1375(1998)
Shen, T., Park, Y.C., Kim, S.H., et al.Nuclear factor-κB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpeneBiol. Pharm. Bull.33(7),1159-1164(2010)
Cárdenas, C., Quesada, A.R., and Medina, M.A.Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpenePLoS One6(8),(2011)
