Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Metabolic regulation of species-specific developmental rates Blebs promote cell survival by assembling oncogenic signalling hubs Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells Primate gastrulation and early organogenesis at single-cell resolution

BTG1 mutation yields supercompetitive B cells primed for malignant transformation A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment Enhanced T cell effector activity by targeting the Mediator kinase module

Modeling post-implantation stages of human development into early organogenesis with stem-cell-derived peri-gastruloids Serotonin reduction in post-acute sequelae of viral infection Hallmarks of Cancer: The Next Generation Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease patholog... Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors

Ketolysis drives CD8+ T cell effector function through effects on histone acetylation The cancer-immunity cycle: Indication, genotype, and immunotype Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionar... Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in... Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung... TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory Genetic subtype-guided immunochemotherapy in diffuse large B cell lymphoma: The randomized GUIDANCE-01 trial Can a biologist fix a radio?—Or, what I learned while studying apoptosis In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter s...

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage ... Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes... The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity

AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansio... A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists Efruxifermin combined with a GLP-1 receptor agonist reduces liver fat in NASH CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT...

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease Tissue morphology influences the temporal program of human brain organoid development Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s... Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immun...

NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration Seasonal light hours modulate peripheral clocks and energy metabolism in mice Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’... Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

Zfp281 and Zfp148 control CD4+ T cell thymic development and TH2 functions Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exe... Emergence and fate of stem cell–like Tcf7+ CD8+ T cells during a primary immune response to viral infection Transcriptomes and metabolism define mouse and human MAIT cell populations CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced inju...

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancer Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors Impaired intracellular Ca2+ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure