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Ailanthone

Cat. No.:YN482727

  • CAS No. :981-15-7

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    • 生物活性
    • 参考文献
    • 产品名称: Ailanthone
      CAS No.: 981-15-7
      Chemical Name: (1β,11β,12α)-11,20-epoxy-1,11,12-trihydroxy-picrasa-3,13(21)-diene-2,16-dione
      Synonyms:Δ13-Dehydrochaparrinone
      分子量:376.40
      分子式:C₂₀H₂₄O₇
      SMILES:C[C@@]1([C@@H]2O)[C@]([C@@]3([C@@H]4O)O)([H])[C@@]([C@](C5)([H])C4=C)(CO3)[C@@](OC5=O)([H])C[C@@]1([H])C(C)=CC2=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Ailanthone (Δ13-Dehydrochaparrinone) 是有效的雄激素受体 (androgen receptor (AR)) 抑制剂, 抑制完整雄激素受体,和持续活跃剪切变体的IC50值分别为 69 nM 和309 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Okunade, A.L., Bikoff, R.E., Casper, S.J., et al.Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)Phytother. Res.17(6),675-677(2003)

      De Feo, V., De Martino, L., Quaranta, E., et al.Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle)J. Agric. Food Chem.51(5),1177-1180(2003)

      He, Y., Peng, S., Wang, J., et al.Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancerNat. Commun.7:13122,(2016)

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