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Bicalutamide

Cat. No.:YN481385

  • CAS No. :90357-06-5

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    • 产品名称: Bicalutamide
      CAS No.: 90357-06-5
      Chemical Name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide
      Synonyms:比卡鲁胺
      分子量:430.37
      分子式:C₁₈H₁₄F₄N₂O₄S
      SMILES:FC1=CC=C(S(=O)(CC(O)(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)C)=O)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Bicalutamide 是一种具有口服活性的非甾体雄激素受体 (AR) 拮抗剂。Bicalutamide 可用于前列腺癌的研究。
      IC50和靶点:
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      In Vivo:
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    • Freeman, S.N., Mainwaring, W.I.P., and Furr, B.J.A.A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334)Br. J. Cancer60(5),664-668(1989)

      Masiello, D., Cheng, S., Bubley, G.J., et al.Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptorJ. Biol. Chem.277(29),26321-26326(2002)

      Gao, W., Kim, J., and Dalton, J.T.Pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligandsPharmacol. Res.23(8),1641-1658(2006)

      Yin, D., Perera, M.A., Dalton, J.T., et al.Key structural features of nonsteroidal ligands for binding and activation of the androgen receptorMol. Pharmacol.63(1),211-223(2003)

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