Dimethylcurcumin
Cat. No.：YN481423
CAS No. ：52328-98-0
规格
价格(RMB)
库存
| 产品名称: | Dimethylcurcumin |
| CAS No.: | 52328-98-0 |
| Chemical Name: | (1E,4Z)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6E-heptatrien-3-one |
| Synonyms: | ASC-J9; GO-Y025 |
| 分子量: | 396.43 |
| 分子式: | C₂₃H₂₄O₆ |
| SMILES: | O=C(/C=C(O)/C=C/C1=CC=C(OC)C(OC)=C1)/C=C/C2=CC=C(OC)C(OC)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dimethylcurcumin (ASC-J9) 是一种雄激素受体降解增强剂，可有效抑制耐药性前列腺癌细胞增殖和侵袭。 |
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Lai, J.-J., Lai, K.-P., Chuang, K.-H., et al.Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expressionJ. Clin. Invest.119(12),3739-3751(2009)
Ma, W.-L., Hsu, C.-L., Wu, M.-H., et al.Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinomaGastroenterology135(3),947-955(2008)
Yang, Z., Chang, Y.-J., Yu, I.-C., et al.ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptorNat. Med.13(3),348-353(2007)
Wen, S., Niu, Y., Lee, S.O., et al.Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cellsMol. Carcinog.55(12),2278-2290(2016)
Xu, J., Lin, H., Li, G., et al.Sorafenib with ASC-J9® synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signalsInt. J. Cancer140(3),705-717(2017)
